This week, I discuss with Patricia Underwood, Ph.D., DABT, MBA, Chief Toxicologist, Principal Director – Chemical and Material Risk Management, Office of the Assistant Secretary of Defense, Department of Defense, and my colleague, Richard E. Engler, Ph.D., Director of Chemistry for B&C and The Acta Group (Acta®), our consulting affiliate, the U.S. Department of Defense’s (DOD) recent Request for Information (RFI) on chemicals undergoing U.S. Environmental Protection Agency (EPA) review as part of the Toxic Substances Control Act (TSCA) Section 6 risk evaluation process. DOD has a significant need for certain chemicals but admittedly has no tracking system for upstream applications of chemicals to understand the implications of EPA’s identification of high priority substances and risk evaluation of them under TSCA Section 6. Dr. Underwood and Dr. Engler discuss the recent RFI issued by DOD to provide this line of sight and they reflect upon the growing importance of supply chain transparency in DOD applications and in the private sector as a whole.